| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595835 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A novel series of triazole integrated phenyl heteroterpenoids have been synthesized and screened for their in vitro activity against intracellular amastigote form of Leishmania donovani. Among all tested compounds, compound 3a was found to be the most active with IC50 6.4 μM and better selectivity index (SI) 18 as compared to reference drugs, miltefosine and miconazole. When evaluated in vivo in L. donovani/hamster model, 3a has exhibited 79 ± 11% inhibition of parasite multiplication at 50 mg kgâ1 Ã 5 days on day 7 post treatment.
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Authors
S.N. Suryawanshi, Avinash Tiwari, Santosh Kumar, Rahul Shivahare, Monika Mittal, Padam Kant, Suman Gupta,