Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595845 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Glycogen synthase (GS) catalyzes the transfer of glucose residues from UDP-glucose to a glycogen polymer chain, a critical step for glucose storage. Patients with type 2 diabetes normally exhibit low glycogen levels and decreased muscle glucose uptake is the major defect in whole body glucose disposal. Therefore, activating GS may provide a potential approach for the treatment of type 2 diabetes. In order to identify non-carboxylic acids GS activators, we designed and synthesized a series of 2-N-alkyl- and 2-N-aryl-indazolone derivatives and studied their activity in activating human GS.
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Authors
Yimin Qian, David Bolin, Karin Conde-Knape, Paul Gillespie, Stuart Hayden, Kuo-Sen Huang, Andrée R. Olivier, Tsutomu Sato, Qing Xiang, Weiya Yun, Xiaolei Zhang,