| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595859 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark J. Mitton-Fry, Steven J. Brickner, Judith C. Hamel, Lori Brennan, Jeffrey M. Casavant, Michael Chen, Tao Chen, Xiaoyuan Ding, James Driscoll, Joel Hardink, Thuy Hoang, Erbing Hua, Michael D. Huband, Meghan Maloney, Anthony Marfat, Sandra P. McCurdy,