| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595870 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A novel series of amide derivatives of lomefloxacin were synthesized and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against a panel of five human cancer cell lines. Of the compounds prepared compounds 9d and 9g exhibited strong inhibition against topoisomerase II at 100 μM. In addition, docking studies were performed to predict the inhibition mode.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
You Zhou, Xiaoli Xu, Yuan Sun, Huaping Wang, Haopeng Sun, Qidong You,