| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595889 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
We synthesized 2,3-dinorprostaglandins, dinor-PGD1, 13-epi-dinor-PGD1, and 13-deoxy-Î10,12-dinor-PGJ1, and examined their effects on the activity of peroxisome proliferator-activated receptors (PPARs). Dinor-PGD1 and 13-epi-dinor-PGD1 were dual agonists for PPARα/γ, in contrast to the highly PPARγ-selective prostaglandins derived from arachidonic acid.
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Authors
Ayato Sato, Kosuke Dodo, Makoto Makishima, Yuichi Hashimoto, Mikiko Sodeoka,