Article ID Journal Published Year Pages File Type
10595920 Bioorganic & Medicinal Chemistry Letters 2013 5 Pages PDF
Abstract
A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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