Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595920 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying-zi Xu, Andrei W. Konradi, Frederique Bard, Michael Dappen, Lilibeth Dofiles, Mark Dreyer, Ian Gallager, Caroline Garrido, Mike Krimm, Zhenmei Liao, Elizabeth Messersmith, Linda Mutter, Michael A. Pleiss, Bhushan Samant, Christopher M. Semko,