Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595977 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A photo-activatable aziridinium precursor has been developed to investigate the possibility of a photo-initiated traditional nucleophilic reaction. The photolysis of a quaternary amine yields a tertiary amine and has allowed us to temporally control aziridinium formation and subsequent alkylation of a colorimetric nucleophilic reporter molecule. We have also used this photo-initiated reaction to alkylate a sulfhydryl group. This new photo-initiated alkylation strategy is water-soluble and expands the toolkit of photo-activated crosslinkers for protein labeling research.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen T. McCarron, Mariel Feliciano, Jeffreys N. Johnson, James J. Chambers,