Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596012 | Bioorganic & Medicinal Chemistry Letters | 2013 | 8 Pages |
Abstract
In the past decade, several kinase inhibitors have been approved based on their clinical benefit for cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary mutations and alternative mechanisms. This review will focus on the cases of acquired resistance to EGFR and ALK inhibitors for non-small cell lung cancer patients and BRAF inhibitors for melanoma patients. I will overview the main causes of acquired resistance, and explore the chemical scaffolds as well as combination of drugs, used to tackle these major causes of resistance.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Simon Giroux,