| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596013 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity towards human growth hormone receptor, reduced cell-based activity, but improved pharmacodynamic properties. We have demonstrated that this CovX-body, given once a week, showed comparable activity as growth hormone given daily in an in vivo hypophysectomized rat model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Moorthy S.S. Palanki, Abhijit Bhat, Ben Bolanos, Florence Brunel, Joselyn Del Rosario, Danielle Dettling, Mark Horn, Rodney Lappe, Ryan Preston, Annette Sievers, Nebojsa Stankovic, Gary Woodnut, Gang Chen,