Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596042 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A novel glycodendrimer based on 18 peripheral α-d-mannoses functionalized perylene bisimide derivative PBI-18-Man was synthesized and its selectively binding interactions for Con A were investigated by CD spectra and turbidity assay, which exhibited strong binding affinity for Con A with the binding constant of 1.3 Ã 108 Mâ1 (7.2 Ã 106 Mâ1 for monomeric mannose, valency corrected), 3 orders of magnitude higher affinity than the monovalent mannose ligand. Furthermore, the inhibitory activity for Con A was studied by ELLA experiment, showed 2 times inhibitor activity than the reference compound (α-MMP).
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ke-Rang Wang, Yue-Qing Wang, Jie Li, Hong-Wei An, Li-Ping Zhang, Jin-Chao Zhang, Xiao-Liu Li,