| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596067 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
This Letter describes the synthesis and biological evaluation of a collection of aminophthalazines capable of reducing PGE2 production in HCA-7 colon cancer cells. A total of twenty eight analogs were tested and active compounds were identified. Furthermore, the anti-tumor activity of analog 2vii was analyzed in xenograft mouse models demonstrating promising anti-cancer activity.
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Authors
Federico Medda, Earlphia Sells, Hui-Hua Chang, Justin Dietrich, Shashi Chappeta, Breland Smith, Vijay Gokhale, Emmanuelle J. Meuillet, Christopher Hulme,