Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596077 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields. The antibacterial activity of the selected products was examined. Some products exhibit promising activities.
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Authors
Bahman Sharifzadeh, Nosrat O. Mahmoodi, Manouchehr Mamaghani, Khalil Tabatabaeian, Alireza Salimi Chirani, Iraj Nikokar,