Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596155 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Posterior capsular opacification (PCO) is the most frequent complication and the primary reason for visual decrease after extracapsular cataract surgery. The proliferation and migration of leftover lens epithelial cells (LECs) after surgery may contribute to the development of PCO. To prevent PCO, a rational approach would be to inhibit both the proliferation and the migration of LECs using nontoxic xenobiotics. Nobiletin, one of the most abundant polymethoxyflavones (PMFs) in citrus peel, and its synthetic congeners displayed a potent inhibition of LEC proliferation. Structural features which enhance anti-proliferative activity have also been discussed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoshiki Miyata, Tetsuta Oshitari, Yuji Okuyama, Arata Shimada, Hideyo Takahashi, Hideaki Natsugari, Hiroshi Kosano,