| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596165 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Optimization of the early lead compound 1 with various carboxamide substitution at the C7 position provided heteroaryl carboxamide analogs (e.g., 35) that exhibited picomolar potency, while the simple methyl amide analog 4 displayed a promising in vitro profile and favorable pharmacokinetic properties in preclinical species.
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Authors
Kap-Sun Yeung, Zhilei Qiu, Quifen Xue, Haiquan Fang, Zheng Yang, Lisa Zadjura, Celia J. D'Arienzo, Betsy J. Eggers, Keith Riccardi, Pei-Yong Shi, Yi-Fei Gong, Marc R. Browning, Qi Gao, Steven Hansel, Kenneth Santone, Ping-Fang Lin,