Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596179 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Two new norditerpenoids, 12-hydroxy-scabrolide A (2), 13-epi-scabrolide C (6) and five know compounds (1, 3-5, 7) were isolated from the methanol extract of the soft coral Sinularia maxima. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Compound 6 potently inhibited IL-12 and IL-6 production in LPS-stimulated bone marrow derived dendritic with IC50 values ranging from 5.30 ± 0.21 to 13.12 ± 0.64 μM. Compound 1 exhibited moderate inhibitory activity against IL-12 and IL-6 production with IC50 values ranging from 23.52 ± 1.37 to 69.85 ± 4.11 μM.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Xuan Cuong, Tran Hong Quang, Pham The Tung, Le Duc Dat, Doobyeong Chae, Sohyun Kim, Young-Sang Koh, Phan Van Kiem, Chau Van Minh, Young Ho Kim,