Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596190 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
In recent years, various biological processes have been found to be regulated by miRNA-mediated gene silencing. A small molecule that modulate the miRNA pathway will provide the biological tool for elucidating mechanisms of miRNA-mediated gene regulation, and can be the drug lead for miRNA related diseases. In this study, we demonstrated that an aminoalkoxy-substituted thioxanthone derivative interferes Dicer-mediated processing of pre-miRNA. Information about the interaction between these xanthone derivatives and pre-miRNAs will enable us to design and develop new small molecule-based inhibitors for miRNA pathway.
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Authors
Asako Murata, Takeo Fukuzumi, Shiori Umemoto, Kazuhiko Nakatani,