Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596196 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
We describe complexes of ruthenium and europium with rigid, 5â²-6-locked 1,10-phenanthroline-containing nucleosides. Both nucleosides were synthesized from condensation of 5-amino-2â²-deoxycytidine with the corresponding diketone. The ruthenium nucleoside displayed fluorescence characteristic of polypyridine ruthenium complexes with a maximum at 616Â nm and a quantum yield of 0.011. Binding of europium to the 1,10-phenanthroline-2,9-diacid moiety of the lanthanide binding nucleoside showed formation of a 1:1 complex with emission at 570-630Â nm, whose emission was enhanced by addition of two phenanthroline ligands. The lanthanide-binding nucleoside was incorporated into DNA oligonucleotides and shown to selectively bind one equivalent of europium ions.
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Authors
Kristmann Gislason, Snorri Th. Sigurdsson,