| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596226 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT2C agonism with excellent selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists](/preview/png/10596226.png "First Page Preview: Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists")
Authors
John M. Fevig, Jianxin Feng, Karen A. Rossi, Keith J. Miller, Ginger Wu, Chen-Pin Hung, Thao Ung, Sarah E. Malmstrom, Ge Zhang, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Qinling Qu, Jinping Gan, Mary Ann Pelleymounter, Jeffrey A. Robl,