Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596228 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Hepatitis C virus (HCV) infection represents a serious health-care problem. Previously we reported the identification of NA255 from our natural products library using a HCV sub-genomic replicon cell culture system. Herein, we report how the absolute stereochemistry of NA255 was determined and an enantioselective synthetic method for NA255 derivatives was developed. The structure-activity relationship of the NA255 derivatives and rat pharmacokinetic profiles of the representative compounds are disclosed.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ken-ichi Kawasaki, Miyako Masubuchi, Tadakatsu Hayase, Susumu Komiyama, Fumio Watanabe, Hiroshi Fukuda, Takeshi Murata, Yasuaki Matsubara, Kouhei Koyama, Hidetoshi Shindoh, Hiroshi Sakamoto, Kohichi Okamato, Atsunori Ohta, Asao Katsume, Masahiro Aoki,