Article ID Journal Published Year Pages File Type
10596228 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract
Hepatitis C virus (HCV) infection represents a serious health-care problem. Previously we reported the identification of NA255 from our natural products library using a HCV sub-genomic replicon cell culture system. Herein, we report how the absolute stereochemistry of NA255 was determined and an enantioselective synthetic method for NA255 derivatives was developed. The structure-activity relationship of the NA255 derivatives and rat pharmacokinetic profiles of the representative compounds are disclosed.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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