| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596255 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Diclofenac (1) significantly inhibited (IC50 = 12 nM) the WT CXCR1/L1.2 cell migration induced by CXCL8 while the efficacy of 1 was completely lost in Lys99Ala CXCR1/L1.2 mutant (IC50 >10 μM).
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Authors
Manolo Rocco Sablone, Maria Candida Cesta, Alessio Moriconi, Andrea Aramini, Cinzia Bizzarri, Claudia Di Giacinto, Rosa Di Bitondo, Isabelle Gloaguen, Massimiliano Aschi, Marcello Crucianelli, Riccardo Bertini, Marcello Allegretti,