| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596294 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Lead-hopping of high throughput screening lead, 1, led to identification of a new potent series, 2, of PDE5 inhibitors. SAR and selectivity data for representatives of this new series are presented.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors](/preview/png/10596294.png "First Page Preview: Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors")
Authors
Dafydd R. Owen, John K. Walker, E. Jon Jacobsen, John N. Freskos, Robert O. Hughes, David L. Brown, Andrew S. Bell, David G. Brown, Christopher Phillips, Brent V. Mischke, John M. Molyneaux, Yvette M. Fobian, Steve E. Heasley, Joseph B. Moon,