| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596300 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency and improved solubility are delineated.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert O. Hughes, John K. Walker, Jerry W. Cubbage, Yvette M. Fobian, D. Joseph Rogier, Steve E. Heasley, Rhadika M. Blevis-Bal, Alan G. Benson, Dafydd R. Owen, E. Jon Jacobsen, John N. Freskos, John M. Molyneaux, David L. Brown, William C. Stallings,