| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596304 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Edmondson, Anthony Mastracchio, Jason M. Cox, George J. Eiermann, Huaibing He, Kathryn A. Lyons, Reshma A. Patel, Sangita B. Patel, Aleksandr Petrov, Giovanna Scapin, Joseph K. Wu, Shiyao Xu, Bing Zhu, Nancy A. Thornberry, Ranabir Sinha Roy,