| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596320 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Four 3â³- and 4â³-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4â³-fluoro analog led to the production of significant levels of IL-2.
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Authors
Ravinder Raju, Bernard F. Castillo, Stewart K. Richardson, Meena Thakur, Ryan Severins, Mitchell Kronenberg, Amy R. Howell,