Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596334 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Chlorosulfonation of 3-methyl[1,2,4]triazolo[4,3-a]pyrimidine with chlorosulfonic acid in the presence of thionyl chloride was studied. When triazolo[4,3-a]pyrimidines are used as substrates, the substitution occurs at C-6. Also the reactivity of the hydrazides (7) towards aldehydes, thioglycolic acid and amines were studies. The newly prepared compounds 10a,d and 11a,d demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10â5Â M level and in some cases at 10â7Â M concentrations.
Related Topics
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Authors
Hend N. Hafez, Abdel-Rahman B.A. El-Gazzar,