Article ID Journal Published Year Pages File Type
10596334 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract
Chlorosulfonation of 3-methyl[1,2,4]triazolo[4,3-a]pyrimidine with chlorosulfonic acid in the presence of thionyl chloride was studied. When triazolo[4,3-a]pyrimidines are used as substrates, the substitution occurs at C-6. Also the reactivity of the hydrazides (7) towards aldehydes, thioglycolic acid and amines were studies. The newly prepared compounds 10a,d and 11a,d demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10−5 M level and in some cases at 10−7 M concentrations.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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