| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596339 | Bioorganic & Medicinal Chemistry Letters | 2009 | 8 Pages |
Abstract
A series of structurally novel 5-benzylthiazole-based stearoyl-CoA desaturase-1 (SCD-1) inhibitors has been identified. Preliminary SAR studies led to the discovery of highly potent and orally available SCD-1 inhibitors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide](/preview/png/10596339.png "First Page Preview: Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide")
Authors
Yoshikazu Uto, Tsuneaki Ogata, Jun Harada, Yohei Kiyotsuka, Yuko Ueno, Yuriko Miyazawa, Hitoshi Kurata, Tsuneo Deguchi, Nobuaki Watanabe, Toshiyuki Takagi, Satoko Wakimoto, Ryo Okuyama, Manabu Abe, Nobuya Kurikawa, Sayako Kawamura, Michiko Yamato,