| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596369 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a 15N-edited HSQC NMR experiment the ligand-Ras binding interface.
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Authors
Alessandro Palmioli, Elena Sacco, Sherwin Abraham, Celestine J. Thomas, Alessandro Di Domizio, Luca De Gioia, Vadim Gaponenko, Marco Vanoni, Francesco Peri,