| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596379 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of icariin derivatives were synthesized. Their multidrug resistance (MDR) reversal activities were evaluated by MTT assay and the results indicated that the derivatives were the potent modulators of MDR. It was showed that the derivatives significantly increased the intracellular accumulation of ADR in MCF-7/ADR cells compared with drug sensitive MCF-7 cells. The results of bi-directional assay and reverse transcription polymerase chain reaction (RT-PCR) assay showed that the derivatives had high inhibitory activity against P-gp efflux function and significantly down-regulated on the expression of P-gp.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dong-Fang Liu, Yan-Ping Li, Tian-Miao Ou, Shi-Liang Huang, Lian-Quan Gu, Min Huang, Zhi-Shu Huang,