| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596437 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We show that iron(II)-phthalocyanines are able to catalyze guanosine oxidation by molecular oxygen in the presence of reducing agents such as ascorbic acid and 2-mercaptoethanol. The products of 5â²-monophosphate-2â²-deoxyguanosine (dGMP) oxidation were directly analyzed using the HPLC-ESI/MS method. The main oxidation products were 5â²-phospho-2â²-deoxy-8-oxo-7,8-dihydroguanine and the 1,N2-glyoxal adduct of the 5â²-monophosphate-2â²-deoxyguanosine.
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Authors
Aleksandra A. Kuznetsova, Lyudmila I. Solovyeva, Oleg L. Kaliya, Evgeniy A. Lukyanets, Dmitri G. Knorre, Olga S. Fedorova,