| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596444 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of water-soluble parthenolide (1) analogs (6-37) were synthesized and evaluated for anti-leukemic activity against primary acute myelogenous (AML) cells in culture. Analogs 16 (R1 = R2 = CH3), 24 (R1 = CH3, R2 = CH2CH2OH) and 30 (R1, R2 = (CH2)2CH(CH3)(CH2)2 had LD50 values in the range 1.6-1.8 μM.
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Authors
Sundar Neelakantan, Shama Nasim, Monica L. Guzman, Craig T. Jordan, Peter A. Crooks,