| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596445 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2â²-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining 379Â mg/L of 6-chloropurine-2â²-deoxyriboside. The obtained compounds can be used as antiviral agents.
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Authors
Cintia W. Rivero, Eliana C. De Benedetti, Jorge E. Sambeth, Mario E. Lozano, Jorge A. Trelles,