Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596450 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to enhance physicochemical properties and potency profile of this class of inhibitors. The synthesis and biological activity of the derived compounds is discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rosanna Tedesco, Deping Chai, Michael G. Darcy, Dashyant Dhanak, Duke M. Fitch, Adam Gates, Victor K. Johnston, Richard M. Keenan, Juili Lin-Goerke, Robert T. Sarisky, Antony N. Shaw, Klara L. Valko, Kenneth J. Wiggall, Michael N. Zimmerman,