Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596452 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at α6â neuronal nicotinic receptors (NNRs) and decrease activation of ganglionic nicotinic receptors, depending on the scaffold. The ramifications of this structure-activity relationship are discussed in the context of the design of small molecules targeting smoking cessation.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott R. Breining, Merouane Bencherif, Sharon R. Grady, Paul Whiteaker, Michael J. Marks, Charles R. Wageman, Henry A. Lester, Daniel Yohannes,