| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596470 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A small library of semi-synthetic analogues of sesquiterpene lactone parthenin was prepared and screened for cytotoxicity. Some of the members displayed significant cytotoxicity in human cervical carcinoma (HeLa) and human myeloid leukemia (HL-60) cells. A few molecules also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Some information about SAR has also been obtained. Interestingly, one of the lead molecules has been found to be the inhibitor of both telomerase and topoisomerase-II.
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Authors
Bhahwal Ali Shah, Rajbir Kaur, Pankaj Gupta, Ajay Kumar, Vijay Kumar Sethi, Samar Singh Andotra, Jaswant Singh, Ajit Kumar Saxena, Subhash Chandra Taneja,