Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596488 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Human hemoglobin (HbA) efficiently catalyses the oxidative aromatization of 1,4-dihydropyridines (1,4-DHPs) and pyrazolines with hydrogen peroxide in phosphate buffer. The results of the study reveal that the rates of oxidative aromatization of 1,4-DHPs are substituent dependent. Thus, the present study is very useful in understanding the metabolism of 1,4-DHP drugs in liver by cytochrome P450 and designing novel drugs as well as modifying the existing drugs for better pharmacokinetic profile.
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Authors
Atul Kumar, Ram Awatar Maurya, Siddharth Sharma,