| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596492 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
SGK1 inhibitors 1 and 2 suffered from poor oral exposure that could be attributed to factors such as high clearance and formation of glucuronic acid conjugates. Incorporation of appropriately-placed substituents was an effective means of reducing clearance and, in some cases, suppressing glucuronidation to provide SGK1 inhibitors with adequate exposure for in vivo studies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marlys Hammond, David G. Washburn, Tram H. Hoang, Sharada Manns, James S. Frazee, Hiroko Nakamura, Jaclyn R. Patterson, Walter Trizna, Charlene Wu, Leonard M. Azzarano, Rakesh Nagilla, Melanie Nord, Rebecca Trejo, Martha S. Head, Baoguang Zhao,