Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596499 | Bioorganic & Medicinal Chemistry Letters | 2012 | 10 Pages |
Abstract
Methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino)ethyl]sulfanyl}benzoate (compound 1) and its derivatives were discovered as compounds having properties of both agonists and allosteric positive modulators of human glucagon-like peptide 2 receptor, a class-B G protein-coupled receptor.
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Authors
Kazuto Yamazaki, Hiroki Terauchi, Daisuke Iida, Hironori Fukumoto, Shuichi Suzuki, Takaki Kagaya, Mika Aoki, Koichiro Koyama, Takashi Seiki, Kazuma Takase, Misako Watanabe, Tohru Arai, Kappei Tsukahara, Junichi Nagakawa,