| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596518 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Previous medicinal chemistry efforts identified a series of phenylalanine derivatives as GPR142 agonists. Optimization of this series led to a tool compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.
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Authors
Xiaohui Du, Yong-Jae Kim, SuJen Lai, Xi Chen, Mike Lizarzaburu, Simon Turcotte, Zice Fu, Qingxiang Liu, Ying Zhang, Alykhan Motani, Kozo Oda, Ryo Okuyama, Futoshi Nara, Michiko Murakoshi, Angela Fu, Jeff D. Reagan, Peter Fan, Yumei Xiong,