Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596524 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pinhong Chen, Lori B. Horton, Rose L. Mikulski, Lisheng Deng, Sandeep Sundriyal, Timothy Palzkill, Yongcheng Song,