| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596537 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.
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Authors
Yong He, Jing Li, Nin Yin, Prudencio S. Herradura, Larry Martel, Yanzhi Zhang, Andre L. Pearson, Vidya Kulkarni, Carmela Mascio, Karen Howland, Jared A. Silverman, Dennis D. Keith, Chester A. Metcalf,