| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596570 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of crown ether fused anilinoquinazolines have been synthesized and evaluated for EGFR inhibition. Compound 12k (Icotinib) showed excellent enzymatic and cellular activities against EGFR. Icotinib is in phase III clinical trials currently.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shaojing Hu, Guojian Xie, Don X. Zhang, Charles Davis, Wei Long, Yunyan Hu, Fei Wang, Xinshan Kang, Fenlai Tan, Lieming Ding, Yinxiang Wang,