Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596575 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
An efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes using secondary diamine as an organocatalyst derived from l-proline and (R)-α-methylbenzyl amine has been described. This pyrrolidine based catalyst 1 was found to be very effective to synthesize various γ-nitrocarbonyl compounds in good yield (up to 81%) with excellent stereoselectivity (up to >99:1 dr and >99% ee).
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Authors
Kamal Nain Singh, Paramjit Singh, Pushpinder Singh, Nand Lal, Sandeep Kumar Sharma,