| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596580 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopic analysis. In addition, the cytotoxic effects of these compounds on human promyelocytic leukemia HL-60 cells were studied. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and trypan blue dye exclusion tests showed that sentulic acid and 3-oxoolean-12-en-27-oic acid were able to induce cytotoxicity in these cells. Furthermore, morphological examination and DNA fragmentation analysis indicated that these cytotoxic effects were mediated by apoptosis.
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Organic Chemistry
Authors
Mai Efdi, Masayuki Ninomiya, Erma Suryani, Kaori Tanaka, Sanusi Ibrahim, Kunitomo Watanabe, Mamoru Koketsu,