| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596583 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
We have developed modified maleimide novel linkers with improved chemical stability that could potentially be used in conjugating various pharmacophores such as oligo nucleotides, peptides, and proteins to antibodies to afford novel biologics with well-defined therapeutic benefits and improved pharmacokinetic properties. These linkers expand the array of tools available for bioconjugation of pharmacophores to antibodies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Moorthy S.S. Palanki, Abhijit Bhat, Rodney W. Lappe, Bin Liu, Bryan Oates, John Rizzo, Nebojsa Stankovic, Curt Bradshaw,