Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596591 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The use of a tri-substituted acylhydrazine as an isostere of a tertiary amide was explored in a series of HCV NS5B thumb site II inhibitors. Direct replacement generated an analog with similar conformational and physicochemical properties. The series was extended to produce compounds with potent binding affinities and encouraging levels of cellular potency.
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Authors
Eda Canales, Joseph S. Carlson, Todd Appleby, Martijn Fenaux, Johnny Lee, Yang Tian, Neeraj Tirunagari, Melanie Wong, William J. Watkins,