Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596601 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Several acyl derivatives of the aureolic acid chromomycin A3 were obtained via lipase-catalyzed acylation. Lipase B from Candida antarctica (CAL-B) was found to be the only active biocatalyst, directing the acylation regioselectively towards the terminal secondary hydroxyl group of the aglycone side chain. All new chromomycin A3 derivatives showed antitumor activity at the micromolar or lower level concentration. Particularly, chromomycin A3 4â²-vinyladipate showed 3-5 times higher activity against the four tumor cell lines assayed as compared to chromomycin A3.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Javier González-SabÃn, Luz Elena Núñez, Nuria Menéndez, Alfredo F. Braña, Carmen Méndez, José A. Salas, Vicente Gotor, Francisco MorÃs,