Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596641 | Bioorganic & Medicinal Chemistry Letters | 2012 | 8 Pages |
Abstract
Indazole fragments were identified by a fragment based approach and optimized by SBDD using information from X-ray structures of ligands bound to the molecular chaperone Hsp90. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity.
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Authors
Hans-Peter Buchstaller, Hans-Michael Eggenweiler, Christian Sirrenberg, Ulrich Grädler, Djordje Musil, Edmund Hoppe, Astrid Zimmermann, Harry Schwartz, Joachim März, Jörg Bomke, Ansgar Wegener, Michael Wolf,