| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596646 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The synthesis and optimization of a series of small molecule Rev-erbα agonists is described. Compounds with good cell-based potency and efficacy and good mouse exposure provides for in vivo probes to interrogate the function of Rev-erbα in animal models of disease.
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Authors
Youseung Shin, Romain Noel, Subhashis Banerjee, Douglas Kojetin, Xinyi Song, Yuanjun He, Li Lin, Michael D. Cameron, Thomas P. Burris, Theodore M. Kamenecka,