| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596655 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
Lead optimization performed on a series of tetracyclic indole-based macrocyclic inhibitors of the HCV NS5b polymerase led to the discovery of TMC647055 (18a), currently in phase 2 clinical trials.
Related Topics
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Authors
Sandrine Vendeville, Tse-I. Lin, Lili Hu, Abdellah Tahri, David McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh,