Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596679 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Biaryl ethers were recently reported as potent NNRTIs. Herein, we disclose a detailed effort to modify the previously reported compound 1. We have designed and synthesized a series of novel pyrazole derivatives as a surrogate for pyrazolopyridine motif that were potent inhibitors of HIV-1 RT with nanomolar intrinsic activity on the WT and key mutant enzymes and potent antiviral activity in infected cells.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dai-Shi Su, John J. Lim, Elizabeth Tinney, Thomas J. Tucker, Sandeep Saggar, John T. Sisko, Bang-Lin Wan, Mary Beth Young, Kenneth D. Anderson, Deanne Rudd, Vandna Munshi, Carolyn Bahnck, Peter J. Felock, Meiquing Lu, Ming-Tain Lai, Sinoeun Touch,